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Question:

BBS1005 SIP QUIZ PT 1

Response:

What does UBF binding signal in the context of nonsense mediated decay?

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UPF is not involved in nonsense mediated decay
The cutting site after alternative splicing 
Incorrect mRNA splicing and initiation of of degregation programming 

How are housekeeping proteins transcribed in a cell?

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Regulated 
Constitutively 

What type of signaling involves hormones ?

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Autocrine 
Paracrine 
Endocrine 
Synaptic 

Select the regulatory protein(s) which activate (s) transcription of the eve gene ?

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Giant 
Kruppel 
Bicoid
Hunchback 

What are the components of the gene expression regulating area on DNA?

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Promoter and cis regulatory sequences 
Terminator and trans regulatory sequences 
Promoter and trans regulatory sequences 
Terminator and cis regulatory sequencing 

To exert their function, transcription regulators have to interact with the DNA helix , to which part of the helix do they usually bind? 

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Minor groove 
Major groove 

Indicate if the following statement is true or false : Opérons are common in eukaryotes 

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True 
False 

A regulatory protein binds to a specific RNA sequence and blocks access of the splicing machinery to a splice junction , what type of regulation is alternative RNA splicing does this example illustrate ? 

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Negative regulation 
Positive regulation 

Select all the true statements regarding the 3" untranslated region of RNA 

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It represents a coding sequence 
3' UTR extends from the stop codon to the start of the poly A tail 
3' extends from the 5' cap to the start codon 
It usually contains the signals responsible for the mRNA localization 

Why is one of the hélices of the helix turn helix proteins called the recognition helix ?

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It binds to the major groove of DNA 
It binds to the minor groove of DNA 

How do the monomers of the leucine zipper proteins form a dimmer which is capable of binding DNA?

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Presence of hydrophillic interactions 
Presence of covalent binds between monomers 
Presence of hydrophobic interactions 

To what DNA sequences do general transcriptional factors bind?

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Promoter regions 
Cis regulatory sequences 

Which transcriptional regulator binds to the TATA box by the means of TBP to initiate transcription ?

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TF2B
TF2D
TF2E
TF2A

How can the binding of transcriptional regulators be stimulated ?

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DNA breathing 
Transformation of the euro chromatine into hétérochromatin 
Previous binding of the transcriptional regulators 

How can the level of activity of Cdk be described in the case of specific cyclin binding ?

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Partially active 
Fully active 

The precursors of which type of micro RNA are synthesized by RNA polymerase 2 ?

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miRNA 
both 
siRNA 

Which part of the RISC complex has the function to cut the targeted RNA molecule ?

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Other components 
miRNA 
siRNA 
Argonaute protein 

Which type of RNA is synthesized by cutting the precursor molecules by Dicer protein?

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miRNA
siRNA 
mRNA

Which protein transforms the primary miRNA to pre-miRNA?

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Exportin 5
Dicer
Argonaute 
Drosha 

What is the function of the Mdm2 protein?

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Activation of p53
Inhibition of p53
Phosphorylation of p53
Signaling DNA damage

What does the extra embryonic mesoderm form from?

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Hypoblast cells 
Heuser's membrane 
Cytotrophoblast cells 

Where do the cells which will form the defenitive yolk sac originate from?

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Hypoblast cells from the first migration 
Epiblast cells 
Hypoblast cells from the 2nd migration 

Which early embryonic tissue is the origin of the cardio genic area?

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Splantic layer of mesoderm 
Somatic layer of mesoderm 
Endoderm