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Question:

BBS1005 SIP QUIZ PT 1

Response:

What does UBF binding signal in the context of nonsense mediated decay?

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UPF is not involved in nonsense mediated decay
Incorrect mRNA splicing and initiation of of degregation programming 
The cutting site after alternative splicing 

How are housekeeping proteins transcribed in a cell?

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Constitutively 
Regulated 

What type of signaling involves hormones ?

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Paracrine 
Endocrine 
Autocrine 
Synaptic 

Select the regulatory protein(s) which activate (s) transcription of the eve gene ?

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Kruppel 
Giant 
Hunchback 
Bicoid

What are the components of the gene expression regulating area on DNA?

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Promoter and cis regulatory sequences 
Promoter and trans regulatory sequences 
Terminator and cis regulatory sequencing 
Terminator and trans regulatory sequences 

To exert their function, transcription regulators have to interact with the DNA helix , to which part of the helix do they usually bind? 

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Minor groove 
Major groove 

Indicate if the following statement is true or false : Opérons are common in eukaryotes 

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False 
True 

A regulatory protein binds to a specific RNA sequence and blocks access of the splicing machinery to a splice junction , what type of regulation is alternative RNA splicing does this example illustrate ? 

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Positive regulation 
Negative regulation 

Select all the true statements regarding the 3" untranslated region of RNA 

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3' extends from the 5' cap to the start codon 
3' UTR extends from the stop codon to the start of the poly A tail 
It usually contains the signals responsible for the mRNA localization 
It represents a coding sequence 

Why is one of the hélices of the helix turn helix proteins called the recognition helix ?

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It binds to the major groove of DNA 
It binds to the minor groove of DNA 

How do the monomers of the leucine zipper proteins form a dimmer which is capable of binding DNA?

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Presence of covalent binds between monomers 
Presence of hydrophobic interactions 
Presence of hydrophillic interactions 

To what DNA sequences do general transcriptional factors bind?

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Promoter regions 
Cis regulatory sequences 

Which transcriptional regulator binds to the TATA box by the means of TBP to initiate transcription ?

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TF2E
TF2B
TF2A
TF2D

How can the binding of transcriptional regulators be stimulated ?

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DNA breathing 
Transformation of the euro chromatine into hétérochromatin 
Previous binding of the transcriptional regulators 

How can the level of activity of Cdk be described in the case of specific cyclin binding ?

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Partially active 
Fully active 

The precursors of which type of micro RNA are synthesized by RNA polymerase 2 ?

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miRNA 
siRNA 
both 

Which part of the RISC complex has the function to cut the targeted RNA molecule ?

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miRNA 
Other components 
siRNA 
Argonaute protein 

Which type of RNA is synthesized by cutting the precursor molecules by Dicer protein?

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miRNA
siRNA 
mRNA

Which protein transforms the primary miRNA to pre-miRNA?

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Exportin 5
Dicer
Drosha 
Argonaute 

What is the function of the Mdm2 protein?

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Activation of p53
Signaling DNA damage
Phosphorylation of p53
Inhibition of p53

What does the extra embryonic mesoderm form from?

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Cytotrophoblast cells 
Heuser's membrane 
Hypoblast cells 

Where do the cells which will form the defenitive yolk sac originate from?

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Epiblast cells 
Hypoblast cells from the 2nd migration 
Hypoblast cells from the first migration 

Which early embryonic tissue is the origin of the cardio genic area?

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Somatic layer of mesoderm 
Endoderm 
Splantic layer of mesoderm